Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination
نویسندگان
چکیده
منابع مشابه
Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension
The role of G-protein activation in cardiovascular disorders is well-known. G-protein β3 subunit (GNB3) C825T polymorphism is associated with increased intracellular signal transduction. We investigated the role of the variant in plasma sodium and potassium concentrations and association with hypertension. 345 healthy controls and 455 patients with essential hypertension were enrolled. Plasma r...
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15 صفحه اولVasovagal syncope patients and the C825T GNB3 polymorphism.
OBJECTIVE The G protein is responsible for signal intracellular transduction and participates in cardiovascular reflexes. C825T polymorphism of the gene encodes the B3 subunit of G protein (GNB3) and causes the increased intracellular signal transduction. The aim was the evaluation GNB3 C825T polymorphism manifestation in vasovagal patients with no other diseases. METHODS In 68 positive tilte...
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15 صفحه اولPhosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination
Conventional ubiquitination involves the ATP-dependent formation of amide bonds between the ubiquitin C terminus and primary amines in substrate proteins. Recently, SdeA, an effector protein of pathogenic Legionella pneumophila, was shown to mediate NAD-dependent and ATP-independent ubiquitin transfer to host proteins. Here, we identify a phosphodiesterase domain in SdeA that efficiently cataly...
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ژورنال
عنوان ژورنال: Cell Discovery
سال: 2016
ISSN: 2056-5968
DOI: 10.1038/celldisc.2016.5